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< Vol. 11 Issue 3 | Sep-Dec 2013 | pp. 129 - 196

Anti-inflammatory entrapment in polycaprolactone/silica hybrid material prepared by sol-gel route, characterization, bioactivity and in vitro release behavior

Abstract

Aim: A novel organic/inorganic hybrid material, based on poly(e-caprolactone) (PCL) and silica (SiO2), were synthesized by the sol-gel method. An anti-inflammatory agent (indomethacin) was incorporated into the hybrid material to verify its local controlled drug delivery system. Methods: The structure of the interpenetrating network was investigated by Fourier transform infrared spectroscopy. The morphology of the materials was studied by scanning electron microscopy. The structure of a molecular level dispersion was disclosed by atomic force microscopy. The bioactivity of the synthesized hybrid materials was revealed by the formation of a layer of hydroxyapatite on the surface of samples soaked in a simulated body fluid (SBF). Release kinetics in SBF were subsequently investigated. The amount of drug released was detected by UV-VIS spectroscopy. Results: Pure anti-inflammatory agent exhibited linear release with time; in contrast, sol-gel silica entrapped drugs were released with a logarithmic time dependence starting with an initial burst effect followed by a gradual decrease.Conclusions: SiO2/PCL (3, 6, 9 and 12 %wt) materials, prepared via sol-gel process, are organic/inorganic hybrid and bioactive materials. All the materials showed a good release and therefore could be used as drug delivery system.

J Appl Biomater Funct Mater 2013; 11(3): 172 - 179

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.9256

Authors

Michelina Catauro, Flavia Bollino

Article History

  • • Available online on 22/06/2012
  • • Published online on 16/12/2013

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Authors

  • Catauro, Michelina [PubMed] [Google Scholar]
    Department of Mechanical and Aerospace Engineering, Second University of Naples, Aversa - Italy
  • Bollino, Flavia [PubMed] [Google Scholar]
    Department of Mechanical and Aerospace Engineering, Second University of Naples, Aversa - Italy

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