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< Vol. 10 Issue 1 | Jan-Apr 2012 | pp. 1 - 66

Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid

Abstract

Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma. Purpose: This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material. Methods: N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement. Results: Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material. Conclusions: The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.

J Appl Biomater Funct Mater 2012; 10(1): 43 - 48

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.9274

Authors

Marija Ð. Vukelic, Žarko J. Mitic, Miroslav S. Miljkovic, Jelena M. Živkovic, Nenad L. Ignjatovic, Dragan P Uskokovic, Jelena Ž. Živanov-Curlis, Perica J. Vasiljevic, Stevo J. Najman

Article History

  • • Accepted on 05/03/2012
  • • Accepted on 05/03/2012
  • • Available online on 29/03/2012
  • • Available online on 23/06/2012
  • • Published online on 26/06/2012

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Authors

  • Vukelic, Marija Ð. [PubMed] [Google Scholar]
    Institute of Biology and Human Genetics, Faculty of Medicine, University of Nis - Serbia
  • Mitic, Žarko J. [PubMed] [Google Scholar]
    Department of Pharmacy, Faculty of Medicine, University of Nis - Serbia
  • Miljkovic, Miroslav S. [PubMed] [Google Scholar]
    Laboratory for Electronic Microscopy, Faculty of Medicine, University of Nis - Serbia
  • Živkovic, Jelena M. [PubMed] [Google Scholar]
    Institute of Biology and Human Genetics, Faculty of Medicine, University of Nis - Serbia
  • Ignjatovic, Nenad L. [PubMed] [Google Scholar]
    Institute for Technical Sciences of the SASA, Belgrade - Serbia
  • Uskokovic, Dragan P [PubMed] [Google Scholar]
    Institute for Technical Sciences of the SASA, Belgrade - Serbia
  • Živanov-Curlis, Jelena Ž. [PubMed] [Google Scholar]
    Institute of Biology and Human Genetics, Faculty of Medicine, University of Nis - Serbia
  • Vasiljevic, Perica J. [PubMed] [Google Scholar]
    Biology and Ecology Department, Faculty of Nature and Sciences, University of Nis - Serbia
  • Najman, Stevo J. [PubMed] [Google Scholar]
    Institute of Biology and Human Genetics, Faculty of Medicine, University of Nis - Serbia

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