Advertisement
< Vol. 11 Issue 3 | Sep-Dec 2013 | pp. 129 - 196

Application of polymer nanocomposites in the nanomedicine landscape: envisaging strategies to combat implant associated infections

Abstract

This review article presents an overview of the potential biomedical application of polymer nanocomposites arising from different chemistries, compositions, and constructions. The interaction between the chosen matrix and the filler is of critical importance. The existing polymer used in the biomedical arena includes aliphatic polyesters such as polylactide (PLA), poly(e-caprolactone) (PCL), poly(p-dioxanone) (PPDO), poly(butylenes succinate) (PBS), poly(hydroxyalkanoate)s, and natural biopolymers such as starch, cellulose, chitin, chitosan, lignin, and proteins. The nanosized fillers utilized to fabricate the nanocomposites are inorganic, organic, and metal particles such as clays, magnetites, hydroxyapatite, nanotubes chitin whiskers, lignin, cellulose, Au, Ag, Cu, etc. These nanomaterials are taking root in a variety of diverse healthcare applications in the sector of nanomedicine including the domain of medical implants and devices. Despite sterilization and aseptic procedures the use of these biomedical devices and prosthesis to improve the patient’s ‘quality of life’ is facing a major impediment because of bacterial colonization causing nosocomial infection, together with the multi-drug-resistant ‘super-bugs’ posing a serious threat to its utility. This paper discusses the current efforts and key research challenges in the development of self-sterilizing nanocomposite biomaterials for potential application in this area.

J Appl Biomater Funct Mater 2013; 11(3): 129 - 142

Article Type: REVIEW

DOI:10.5301/JABFM.2013.11544

Authors

Poushpi Dwivedi, Shahid S. Narvi, Ravi P. Tewari

Article History

  • • Accepted on 30/11/2012
  • • Available online on 15/10/2013
  • • Published online on 16/12/2013

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

  • Dwivedi, Poushpi [PubMed] [Google Scholar]
    Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, UP - India
  • Narvi, Shahid S. [PubMed] [Google Scholar]
    Department of Chemistry, Motilal Nehru National Institute of Technology, Allahabad, UP - India
  • Tewari, Ravi P. [PubMed] [Google Scholar]
    Department of Applied Mechanics, Motilal Nehru National Institute of Technology, Allahabad, UP - India

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.