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< Vol. 11 Issue 2 | May-Aug 2013 | pp. 73 - 128

Assessment of cellular reactions to magnesium as implant 
material in comparison to titanium and to glyconate using 
the mouse tail model

Abstract

Purpose: Nowadays, research in magnesium alloys as a biodegradable implant material has increased. The aim of this study was to examine osteoinductive properties and tissue responses to pure magnesium in comparison to conventional permanent (titanium) and to degradable (glyconate) implant materials.
Methods: Magnesium wires (0.4 mm in diameter, 10 mm length) were implanted into tail veins of mice and examined after 2, 4, 8, 16 and 32 weeks. Titanium and glyconate as controls were assessed after 2, 4, 8 and 24 weeks. µ-computed tompgraphy, histology and SEM examinations were performed. 
Results: Magnesium implants showed increasing structural losses over time with fragmentation after an observation period of 32 weeks. Glyconate was fully degraded and titanium remained almost unaffected after 24 weeks. In contrast to some titanium and glyconate implants, first calcium and phosphate precipitations could be observed around magnesium implants after two weeks. However, ossification could not be observed even after 32 weeks, whereas enchondral ossification was found partially in the sourrounding of glyconate and titanium implants after eight weeks. Nevertheless, magnesium implants showed less inflammatory responses and fibrosing properties than the conventional implant materials. 
Conclusions: Although the assumed osteoinductive properties could not be detected, magnesium appears to be a promising degradable implant material because of the low sensitizing and inflammatory potential.

J Appl Biomater Funct Mater 2013; 11(2): 89 - 94

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.5000150

Authors

Janin Reifenrath, Muhammad Badar, Dina Dziuba, Peter P. Müller, Torsten Heidenblut, Alexander Bondarenko, Andrea Meyer-Lindenberg

Article History

  • • Accepted on 28/11/2012
  • • Available online on 31/05/2013
  • • Published online on 13/09/2013

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Authors

  • Reifenrath, Janin [PubMed] [Google Scholar]
    Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover - Germany
  • Badar, Muhammad [PubMed] [Google Scholar]
    Helmholtz Centre for Infection Research, Braunschweig - Germany
  • Dziuba, Dina [PubMed] [Google Scholar]
    Small Animal Clinic, University of Veterinary Medicine Hannover, Hannover - Germany
  • Müller, Peter P. [PubMed] [Google Scholar]
    Helmholtz Centre for Infection Research, Braunschweig - Germany
  • Heidenblut, Torsten [PubMed] [Google Scholar]
    Institute of Materials Science, Leibniz University Hannover, Garbsen - Germany
  • Bondarenko, Alexander [PubMed] [Google Scholar]
    Department of Pathology, Dnipropetrovs’k State Medical Academy, Dnipropetrovs’k - Ukraine
  • Meyer-Lindenberg, Andrea [PubMed] [Google Scholar]
    Clinic for Small Animal Surgery and Reproduction, Centre of Clinical Veterinary Medicine, Ludwig Maximilian University München, München - Germany

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