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< Vol. 12 Issue 3 | Sep-Dec 2014 | pp. 113 - 285

Biomechanical properties: effects of low-level laser therapy and Biosilicate® on tibial bone defects in osteopenic rats

Abstract

Purpose

The aim of this study was to investigate the effects of laser therapy and Biosilicate® on the biomechanical properties of bone callus in osteopenic rats.

 Methods

Fifty female Wistar rats were equally divided into 5 groups (n=10/group): osteopenic rats with intact tibiae (SC); osteopenic rats with unfilled and untreated tibial bone defects (OC); osteopenic rats whose bone defects were treated with Biosilicate® (B); osteopenic rats whose bone defects were treated with 830-nm laser, at 120 J/cm2 (L120) and osteopenic rats whose bone defects were treated with Biosilicate® and 830-nm laser, at 120 J/cm2 (BL120). Ovariectomy (OVX) was used to induce osteopenia. A non-critical bone defect was created on the tibia of the osteopenic animals 8 weeks after OVX. In Biosilicate® groups, bone defects were completely filled with the biomaterial. For the laser therapy, an 830-nm laser, 120 J/cm2 was used. On day 14 postsurgery, rats were euthanized, and tibiae were removed for biomechanical analysis.

 Results

Maximal load and energy absorption were higher in groups B and BL120, according to the indentation test. Animals submitted to low-level laser therapy (LLLT) did not show any significant biomechanical improvement, but the association between Biosilicate® and LLLT was shown to be efficient to enhance callus biomechanical properties. Conversely, no differences were found between study groups in the bending test.

 Conclusions

Biosilicate® alone or in association with low level laser therapy improves biomechanical properties of tibial bone callus in osteopenic rats.

J Appl Biomater Funct Mater 2014; 12(3): 271 - 277

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/jabfm.5000198

Authors

Renan Fangel, Paulo S. Bossini, Ana Cláudia Renno, Renata N. Granito, Charles C. Wang, Keico O. Nonaka, Patricia Driusso, Nivaldo A. Parizotto, Jorge Oishi

Article History

  • • Accepted on 08/05/2013
  • • Available online on 30/03/2014
  • • Published online on 30/12/2014

Disclosures

Financial support: This work was funded by the Brazilian funding agency Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES. CAPES is a foundation within the Ministry of Education (MEC).
Conflict of interest: The authors declare they have no conflicts of interest.

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Authors

Affiliations

  • Department of Physiotherapy, Federal University of São Carlos (UFSCar), São Carlos, SP - Brazil
  • Department of Bioscience, Federal University of Sao Paulo (UNIFESP), Santos, SP - Brazil
  • Department of Biology, Federal University of São Carlos (UFSCar), São Carlos, SP - Brazil
  • Department of Statistics, Federal University of São Carlos (UFSCar), São Carlos, SP - Brazil

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