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< Vol. 14 Issue 2 | Apr-Jun 2016 | pp. e129 - e222

A double-layer patch design for local and controlled drug delivery as an intraoperative custom-made implant-coating technology

Abstract

Background

The specific biological need of patients frequently becomes obvious just in the intraoperative setting. We hypothesized that a double-layer patch approach that allowed rapid attachment to an implant surface would represent a potential solution for technically challenging intraoperative personalized local drug delivery.

 Methods

Dexamethasone-loaded poly[(rac-lactide)-co-glycolide] (PLGA) microparticles were embedded within a polyvinyl alcohol (PVA) patch that was attached to metal implant surfaces by in situ polymerization of alkyl-2-cyanoacrylates (CAs). Hydroxyapatite (HA) nanoparticles were also embedded in the PVA patch.

 Results

Very rapid dexamethasone-release profiles were observed from the PLGA microparticles / PVA patches. The incorporation of HA nanoparticles into the PVA enabled control of CA penetration within the patch, and improved significantly its attachment, while no interference with the drug release was observed.

 Conclusions

Double-layered patches with 1 layer for drug delivery and 1 as gluing interface could represent a solution for safe and controlled local drug delivery from implant surfaces or other, even biological, materials. The technology platform presented here opens the opportunity for personalized medicine by allowing local administration of drugs with customized release based on an intraoperative application.

J Appl Biomater Funct Mater 2016; 14(2): e143 - e153

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/jabfm.5000270

Authors

Branko Trajkovski, Ansgar Petersen, Carsten Perka, Nico Scharnagl, Simi Mathew, Christian Wischke, Andreas Lendlein, Georg N. Duda

Article History

  • • Accepted on 16/12/2015
  • • Available online on 29/04/2016
  • • Published online on 18/05/2016

Disclosures

Financial support: B.T. was supported by DFG funding from the Berlin School for Regenerative Therapies (GSC 203). We also want to extend our thanks for the generous donations from Synthes GmbH, AAP Implantate AG and P.J. Dahlhausen & Co. GmbH.
Conflict of interest: None of the authors has any financial interest related to this study to disclose.

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Authors

Affiliations

  • Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Berlin - Germany
  • Berlin-Brandenburg School for Regenerative Therapies, Berlin - Germany
  • Berlin-Brandenburg Center for Regenerative Therapies, Berlin and Teltow - Germany
  • Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Berlin - Germany
  • Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Teltow - Germany

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