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< Vol. 10 Issue 3 | Sep-Dec 2012 | pp 163 - 314 - Focus on Advanced Functional Polymers for Medicine

Combinatorial synthesis of photo-crosslinked biodegradable networks

Abstract

Purpose: Photo-crosslinking is a technique that can accelerate the development of novel polymeric biomaterials. 
Methods: Here we show the development of a combinatorial platform to synthesize numerous synthetic biodegradable and biocompatible networks by photo-crosslinking mixtures of macromers. 
Results: Combinations of dimethacrylate-terminated macromers based on hydrophobic D,L-lactide (DLLA), trimethylene carbonate (TMC), epsilon-caprolactone (CL), and hydrophilic polyethylene glycol (PEG) were crosslinked into polymer networks with widely differing properties. The interaction of cells with the network surfaces was assessed by an in vitro cell seeding experiment in which cell proliferation was assessed using a DNA proliferation assay. 
Conclusions: In this way, a hydrophilic material was identified that unexpectedly supported the proliferation of cells very well.

J Appl Biomater Funct Mater 2012; 10(3): 197 - 202

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.10344

Authors

Erwin Zant, Mirjam J. Bosman, Dirk W. Grijpma

Article History

  • • Accepted on 11/10/2012
  • • Available online on 10/12/2012
  • • Published in print on 13/02/2013

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Authors

  • Zant, Erwin [PubMed] [Google Scholar]
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Biomaterials Science and Technology, University of Twente, Enschede - The Netherlands
  • Bosman, Mirjam J. [PubMed] [Google Scholar]
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Biomaterials Science and Technology, University of Twente, Enschede - The Netherlands
  • Grijpma, Dirk W. [PubMed] [Google Scholar]
    MIRA Institute for Biomedical Technology and Technical Medicine, Department of Biomaterials Science and Technology, University of Twente, Enschede - The Netherlands and W.J. Kolff Institute, Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, Groningen - The Netherlands

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