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< Vol. 10 Issue 1 | Jan-Apr 2012 | pp. 1 - 66

Dissolution medium responsive simvastatin release from biodegradable apatite cements and the therapeutic effect in osteoporosis rats

Abstract

Bio-convertible artificial bone with slow release of anti-osteoporosis drug is useful to treat osteoporosis. Apatite cement containing 6% simvastatin (APD) had lower crystallinity than natural bone. In-vitro drug release tests in simulated body fluid (pH 7.8) and acetate buffer (pH 4.5) were performed at 37.0 C as physical models of osteoblast and osteoclast conditions (SOB and SOC). The device had lower drug release rate under SOB, but significantly higher rates under SOC. The simvastatin release rate changed depending on dissolution media, it repeated twice, and the rate under SOC was 15 times higher than under SOB. The device showed dissolution medium responsive drug release. After implantation of the APD in osteoporosis rats, the bone mineral density was evaluated by the x-ray computed tomography. The result indicated that the bone mineral density of APD implanted rat was significantly higher than that of control diseased. The result indicated that the device was therapeutically useful to bone regeneration.

J Appl Biomater Funct Mater 2012; 10(1): 22 - 28

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.9272

Authors

Hideyuki Hamada, Hiroyuki Ohshima, Makoto Otsuka, Hideyuki Hamada

Article History

  • • Accepted on 09/06/2011
  • • Accepted on 09/06/2011
  • • Available online on 15/02/2012
  • • Available online on 23/06/2012
  • • Published online on 26/06/2012

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Authors

  • Hamada, Hideyuki [PubMed] [Google Scholar]
    Graduate School of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba - Japan
  • Ohshima, Hiroyuki [PubMed] [Google Scholar]
    Graduate School of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba - Japan
  • Otsuka, Makoto [PubMed] [Google Scholar]
    Graduate School of Pharmaceutical Sciences, Musashino University, Shinmachi, Nishi-Tokyo - Japan
  • Hamada, Hideyuki [PubMed] [Google Scholar]
    Graduate School of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba - Japan

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