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< Vol. 11 Issue 1 | Jan-Apr 2013 | pp. 1 - 71

Hydrophilic gelatin and hyaluronic acid-treated PLGA scaffolds for cartilage tissue engineering

Abstract

Tissue engineering provides a new strategy for repairing damaged cartilage. Surface and mechanical properties of scaffolds play important roles in inducing cell growth.
Aim: The aim of this study was to fabricate and characterize PLGA and gelatin/hyaluronic acid-treated PLGA (PLGA-GH) sponge scaffolds for articular cartilage tissue engineering. Methods: The PLGA-GH scaffolds were cross-linked with gelatin and hyaluronic acid. Primary chondrocytes isolated from porcine articular cartilages were used to assess cell compatibility. The characteristic PLGA-GH scaffold was higher in water uptake ratio and degradation rate within 42 days than the PLGA scaffold. Results: The mean compressive moduli of PLGA and PLGA-GH scaffolds were 1.72±0.50 MPa and 1.86±0.90 MPa, respectively. The cell attachment ratio, proliferation, and extracellular matrix secretion on PLGA-GH scaffolds are superior to those of PLGA scaffolds. Conclusions: In our study, PLGA-GH scaffolds exhibited improvements in cell biocompatibility, cell proliferation, extracellular matrix synthesis, and appropriate mechanical and structural properties for potential engineering cartilage applications.

J Appl Biomater Funct Mater 2013; 11(1): 45 - 52

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.9253

Authors

Nai-Jen Chang, Yi-Ru Jhung, Chih-Kai Yao, Ming-Long Yeh

Article History

  • • Accepted on 16/12/2011
  • • Available online on 22/06/2012
  • • Published online on 24/06/2013

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Authors

  • Chang, Nai-Jen [PubMed] [Google Scholar]
    Institute of Biomedical Engineering, National Cheng Kung University, Tainan City - Taiwan
  • Jhung, Yi-Ru [PubMed] [Google Scholar]
    Institute of Biomedical Engineering, National Cheng Kung University, Tainan City - Taiwan
  • Yao, Chih-Kai [PubMed] [Google Scholar]
    Department of Material Science and Engineering, National Cheng Kung University, Tainan City - Taiwan
  • Yeh, Ming-Long [PubMed] [Google Scholar]
    Institute of Biomedical Engineering, National Cheng Kung University, Tainan City - Taiwan and Medical Device Innovation Center, National Cheng Kung University, Tainan City - Taiwan

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