Advertisement
< Vol. 10 Issue 3 | Sep-Dec 2012 | pp 163 - 314 - Focus on Advanced Functional Polymers for Medicine

Influence of co-monomer ratio on the chemical properties and cytotoxicity of poly[acrylonitrile-co-(N-vinylpyrrolidone)] nanoparticles

Abstract

Purpose. A system of nanoparticles with varying hydrophilicities may include promising biomaterial candidates as they offer various cellular uptake properties and a range of drug encapsulation efficacies, which would be advantageous in regenerative therapies. Therefore, a model system of nanoparticles with varying hydrophilicities was synthesized and assessed for its candidacy as a biomaterial.Methods. Here, acrylonitrile (AN) was copolymerized with N-vinylpyrrolidone (NVP) in a mini-emulsion to form a family of nanoparticles, thereby enabling the systematic variation of the copolymer hydrophilicity. The nanoparticles based on these copolymers were prepared and characterized using 1H-NMR, dynamic light scattering, differential scanning calorimetry, and thermal gravimetric analysis. Finally, the cytotoxicity of the nanoparticles was assessed by conducting indirect tests using L929 fibroblasts.
Results. The nanoparticles showed well controlled NVP/AN molar ratios as determined by 1H NMR, well defined diameters ranging from approximately 100 nm to 200 nm, and increasing glass transition temperatures with increasing molar NVP content. Finally, L929 fibroblasts only slightly changed their morphology upon incubation with material eluates.
Conclusions. Poly[acrylonitrile-co-(N-vinylpyrrolidone)] nanoparticles with varying amounts of NVP were shown to be a promising model system for further biological assessment.

J Appl Biomater Funct Mater 2012; 10(3): 308 - 314

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.10430

Authors

Wenzhong Li, Benjamin Franklin Pierce, Nico Scharnagl, Christian Wischke, Adam Lee Sisson, Andreas Lendlein

Article History

  • • Accepted on 04/10/2012
  • • Available online on 18/12/2012
  • • Published in print on 13/02/2013

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

  • Li, Wenzhong [PubMed] [Google Scholar]
    Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow - Germany
  • Pierce, Benjamin Franklin [PubMed] [Google Scholar]
    Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow - Germany
  • Scharnagl, Nico [PubMed] [Google Scholar]
    Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow - Germany
  • Wischke, Christian [PubMed] [Google Scholar]
    Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow - Germany
  • Sisson, Adam Lee [PubMed] [Google Scholar]
    Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow - Germany
  • Lendlein, Andreas [PubMed] [Google Scholar]
    Center for Biomaterial Development and Berlin-Brandenburg Centre for Regenerative Therapies, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Teltow - Germany

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.