Abstract
In this study, we fabricated prototype bicomponent polyester/silk fibroin small-diameter arterial prostheses using a specially designed narrow ribbon shuttle loom.
The 2-layered flat fabrics were then heatset on a mandrel to form tubes with a round cross section.
The woven samples had a wall thickness between 0.23 mm and 0.29 mm and an inner diameter between 3.53 mm and 3.95 mm, depending on the yarn type and the weave structure.
The bicomponent polyester/silk fibroin samples had superior bursting strength, circumferential strength and suture retention strength compared with a commercial small-diameter arterial prosthesis made from ePTFE. In addition, these prototype samples had greater suture retention strengths than a dog femoral artery, which indicates that they have adequate biostability for clinical use. While their amount of radial compliance was superior to that of the ePTFE commercial graft control, it did not match that of a natural artery. So there is still a need for future improvement in compliance. All of the woven prototypes had water permeability values between 26 and 180 ml/(cm2*min), which confirms that none of these arterial prostheses needs to be preclotted at the time of implantation. The biocompatibility of the woven prototypes was evaluated using porcine endothelial cells and an MTT assay. Their cytocompatibility was found to be superior to the ePTFE commercial control, and the level of cell attachment was observed to increase on these prototypes woven with a higher silk fibroin content.
J Appl Biomater Funct Mater 2015; 13(3): e201 - e209
Article Type: ORIGINAL RESEARCH ARTICLE
DOI:10.5301/jabfm.5000225
Authors
Xiaoyuan Yang, Lu Wang, Guoping Guan, Hongqi Zhang, Gaotian Shen, Ying Guan, Lei Peng, Yuling Li, Martin W. KingArticle History
- • Accepted on 21/01/2015
- • Available online on 12/06/2015
- • Published online on 16/10/2015
Disclosures
This article is available as full text PDF.
Authors
- Yang, Xiaoyuan [PubMed] [Google Scholar] 1, 2
- Wang, Lu [PubMed] [Google Scholar] 1, * Corresponding Author ([email protected])
- Guan, Guoping [PubMed] [Google Scholar] 1
- Zhang, Hongqi [PubMed] [Google Scholar] 3
- Shen, Gaotian [PubMed] [Google Scholar] 1
- Guan, Ying [PubMed] [Google Scholar] 1
- Peng, Lei [PubMed] [Google Scholar] 1
- Li, Yuling [PubMed] [Google Scholar] 1
- King, Martin W. [PubMed] [Google Scholar] 1, 2
Affiliations
-
Key Lab of Textile Science and Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai - PR China -
College of Textiles, North Carolina State University, Raleigh, North Carolina - USA -
Shanghai Medical College, Fudan University, Shanghai - PR China
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