Advertisement
< Vol. 12 Issue 3 | Sep-Dec 2014 | pp. 113 - 285

Mechanical study of polycaprolactone-hydroxyapatite porous scaffolds created by porogen-based solid freeform fabrication method

Abstract

Materials and Methods: Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds with 600-µm pore size were fabricated by drop-on-demand printing (DDP) structured porogen method followed with injection molding. Specimens with special dimensions of 4.2×4.2×5.4 mm3 and 6.6×6.6×13.8 mm3 were designed and fabricated for compression and tensile tests, respectively. The mechanical study was performed on both solid and porous PCL and PCL-HA samples. The effect on mechanical properties of the HA content ratio in PCL-HA composites was investigated. Results: Porous scaffold made of 80/20 PCL-HA composite had an ultimate compressive strength of 3.7±0.2 MPa and compression modulus of 61.4±3.4 MPa, which is in the range of reported trabecular bone’s compressive strength. Increasing the concentration of HA in the composites raised compressive properties and stiffness significantly (P>0.05), which demonstrates that PCL-HA composites have the potential for application in bone regeneration. Tensile test of solid PCL and PCL-HA composites showed that the ultimate tensile strength and tensile modulus increased with increases of the concentration of HA in the composites. The tensile test was also conducted on PCL porous scaffold; the result indicated that the scaffold was slightly softer and weaker in tension compared with compression. Conclusions: Combining compression and tensile test results, our study may guide the possible application of these biomaterials in bone tissue engineering and support further development of microstructure-based models of scaffold mechanical properties.

J Appl Biomater Funct Mater 2014; 12(3): 145 - 154

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.5000163

Authors

Lin Lu, Qingwei Zhang, David M. Wootton, Richard Chiou, Dichen Li, Bingheng Lu, Peter I. Lelkes, Jack Zhou

Article History

  • • Accepted on 22/06/2012
  • • Available online on 14/01/2014
  • • Published online on 30/12/2014

This article is available as full text PDF.

  • If you are a Subscriber, please log in now.

  • Article price: Eur 36,00
  • You will be granted access to the article for 72 hours and you will be able to download any format (PDF or ePUB). The article will be available in your login area under "My PayPerView". You will need to register a new account (unless you already own an account with this journal), and you will be guided through our online shop. Online purchases are paid by Credit Card through PayPal.
  • If you are not a Subscriber you may:
  • Subscribe to this journal
  • Unlimited access to all our archives, 24 hour a day, every day of the week.

Authors

  • Lu, Lin [PubMed] [Google Scholar]
    Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania - USA
  • Zhang, Qingwei [PubMed] [Google Scholar]
    Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania - USA
  • Wootton, David M. [PubMed] [Google Scholar]
    Mechanical Engineering, Cooper Union for the Advancement of Science and Art, New York City, New York - USA
  • Chiou, Richard [PubMed] [Google Scholar]
    Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania - USA
  • Li, Dichen [PubMed] [Google Scholar]
    School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi - China
  • Lu, Bingheng [PubMed] [Google Scholar]
    School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an, Shaanxi - China
  • Lelkes, Peter I. [PubMed] [Google Scholar]
    Department of Bioengineering, Temple University, Philadelphia, Pennsylvania - USA
  • Zhou, Jack [PubMed] [Google Scholar]
    Department of Mechanical Engineering and Mechanics, Drexel University, Philadelphia, Pennsylvania - USA

Article usage statistics

The blue line displays unique views in the time frame indicated.
The yellow line displays unique downloads.
Views and downloads are counted only once per session.

No supplementary material is available for this article.