Mesoporous bioactive glass as a multifunctional system for bone regeneration and controlled drug release

Baino, Francesco; Baino, Francesco; Fiorilli, Sonia; Fiorilli, Sonia; Mortera, Renato; Mortera, Renato; Onida, Barbara; Onida, Barbara; Saino, Enrica; Saino, Enrica; Visai, Livia; Visai, Livia; Verné, Enrica; Verné, Enrica; Vitale-Brovarone, Chiara; Vitale-Brovarone, Chiara

doi:10.5301/JABFM.2012.9270

Mesoporous bioactive glass as a multifunctional system for bone regeneration and controlled drug release

Abstract

Purpose: Coupling the potential for bone regeneration and the ability for in situ controlled drug release in a single device is a challenging field of research in bone tissue engineering; in an attempt to pursue this aim, mesoporous bioactive glass (MBG) membranes belonging to the SiO2-P2O5-CaO ternary system were produced and characterized. Methods: The glass was synthesized via a sol-gel route coupled with an evaporation-induced self-assembly process by using a non-ionic block co-polymer as a mesostructure former. MBG structure and morphology, as well as mesopores size and shape, were investigated by x-ray diffraction, transmission electron microscopy, and N2 adsorption-desorption measurements. In vitro bioactivity was investigated by soaking MBG membranes in simulated body fluid (SBF) for different time frames. Ibuprofen was encapsulated into MBG pores and drug release kinetics in SBF were assessed. Biological tests by using SAOS-2 cells were performed to assess the material cytocompatibility. Results: The material revealed significant ability to induce hydroxyapatite formation on its surface (bioactivity). Drug release kinetics in SBF are very similar to those obtained for mesoporous silica having mesopore size comparable to that of the prepared MBG (∼5 nm). No evidence of cell viability depression was detected during in vitro culture, which demonstrates the good biological compatibility of the material. Conclusions: The easiness of tailoring and shaping, the highly bioactive and biocompatible behavior, and the drug uptake/release ability of the prepared materials may suggest their use as “smart” multifunctional grafts for bone reconstructive surgery.

J Appl Biomater Funct Mater 2012; 10(1): 12 - 21

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.9270

Authors

Francesco Baino, Francesco Baino, Sonia Fiorilli, Sonia Fiorilli, Renato Mortera, Renato Mortera, Barbara Onida, Barbara Onida, Enrica Saino, Enrica Saino, Livia Visai, Livia Visai, Enrica Verné, Enrica Verné, Chiara Vitale-Brovarone, Chiara Vitale-Brovarone

Article History

• Accepted on 20/06/2011
• Accepted on 20/06/2011
• Available online on 15/02/2012
• Available online on 23/06/2012
• Published online on 26/06/2012

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Authors

Baino, Francesco [PubMed] [Google Scholar]
Baino, Francesco [PubMed] [Google Scholar]
Applied Science and Technology Department, Politecnico di Torino, Torino - Italy
Fiorilli, Sonia [PubMed] [Google Scholar]
Applied Science and Technology Department, Politecnico di Torino, Torino - Italy
Fiorilli, Sonia [PubMed] [Google Scholar]
Mortera, Renato [PubMed] [Google Scholar]
Applied Science and Technology Department, Politecnico di Torino, Torino - Italy
Mortera, Renato [PubMed] [Google Scholar]
Onida, Barbara [PubMed] [Google Scholar]
Onida, Barbara [PubMed] [Google Scholar]
Applied Science and Technology Department, Politecnico di Torino, Torino - Italy
Saino, Enrica [PubMed] [Google Scholar]
Department of Molecular Medicine, Medicine Section, University of Pavia, Pavia - Italy; Center for Tissue Engineering (CIT), University of Pavia, Pavia, Italy
Saino, Enrica [PubMed] [Google Scholar]
Visai, Livia [PubMed] [Google Scholar]
Department of Molecular Medicine, Medicine Section, University of Pavia, Pavia - Italy; Center for Tissue Engineering (CIT), University of Pavia, Pavia, Italy; ”S. Maugeri” Foundation, IRCCS, Pavia - Italy; International Centre For Studies and Research In Biomedicine (ICB) - Luxembourg
Visai, Livia [PubMed] [Google Scholar]
Verné, Enrica [PubMed] [Google Scholar]
Applied Science and Technology Department, Politecnico di Torino, Torino - Italy
Verné, Enrica [PubMed] [Google Scholar]
Vitale-Brovarone, Chiara [PubMed] [Google Scholar]
Applied Science and Technology Department, Politecnico di Torino, Torino - Italy
Vitale-Brovarone, Chiara [PubMed] [Google Scholar]

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