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< Vol. 12 Issue 3 | Sep-Dec 2014 | pp. 113 - 285

Physical properties and biocompatibility of oligochitosan membrane film as wound dressing

Abstract

Background

The physical and biological characteristics of oligochitosan (O-C) film, including its barrier and mechanical properties, in vitro cytotoxicity and in vivo biocompatibility, were studied to assess its potential use as a wound dressing.

 Methods

Membrane films were prepared from water-soluble O-C solution blended with various concentrations of glycerol to modify the physical properties of the films. In vitro and in vivo biocompatibility evaluations were performed using primary human skin fibroblast cultures and subcutaneous implantation in a rat model, respectively.

 Results

Addition of glycerol significantly influenced the barrier and mechanical properties of the films. Water absorption capacity was in the range of 80%-160%, whereas water vapor transmission rate varied from 1,180 to 1,618 g/m2 per day. Both properties increased with increasing glycerol concentration. Tensile strength decreased while elongation at break increased with the addition of glycerol. O-C films were found to be noncytotoxic to human fibroblast cultures and histological examination proved that films are biocompatible.

 Conclusion

These results indicate that the membrane film from O-C has potential application as a wound-dressing material.

J Appl Biomater Funct Mater 2014; 12(3): 155 - 162

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/jabfm.5000190

Authors

Zanariah Ujang, Ahmad Hazri Abdul Rashid, Siti Kasmarizawaty Suboh, Ahmad Sukari Halim, Chin Keong Lim

Article History

  • • Accepted on 07/10/2013
  • • Available online on 30/03/2014
  • • Published online on 30/12/2014

Disclosures

Financial support: Funding was received as a grant from the Intensification of Research in Priority Area Program (IRPA), Ministry of Science, Technology and Innovation (MOSTI), Malaysia (grant 03-01-01-0070 PR 0071/05-03).
Conflict of interest statement: None to declare.

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Authors

Affiliations

  • Industrial Biotechnology Research Center, SIRIM Berhad, Shah Alam, Selangor - Malaysia
  • School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan - Malaysia
  • Skin Research and Innovation Centre, Research and Development Division, Wipro Manufacturing Services Sdn Bhd, Subang Jaya, Selangor - Malaysia

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