Abstract
Purpose: The aim of this study was to design and build porous microstructures with shape memory behaviour using biodegradable poly(D,L-lactide-co-trimethylene carbonate) dimethacrylate macromers. These microstructures could be advantageous for tissue engineering and other advanced biomedical applications.
Methods: Porous structures with a gyroid pore network architecture showing average pore sizes of 930 µm and complete pore interconnectivity were prepared by stereolithography. Built structures were characterized by Micro-computed tomography (µ-CT). Shape recovery and shape fixity of microstructures after 40% and 70% compression were evaluated.
Results: At 37 °C the flexible structures showed compression modulus values of 60 KPa and could be fully compressed. Thermal analysis showed that the built networks were amorphous with Tg values of 23 °C. After compression to 40 and 70%, shape fixity and shape recovery of the structures at respectively 0 °C and 37 °C was almost quantitative.
Conclusions: The well-defined pore network characteristics and the shape-memory properties of these structures allow their use as deployable tissue engineering scaffolds.
J Appl Biomater Funct Mater 2012; 10(3): 280 - 286
Article Type: ORIGINAL RESEARCH ARTICLE
DOI:10.5301/JABFM.2012.10367
Authors
Shahriar Sharifi, Sebastien Blanquer, Dirk W. Grijpma
Article History
- • Accepted on 25/10/2012
- • Available online on 13/12/2012
- • Published in print on 13/02/2013
This article is available as full text PDF.
Authors
- Sharifi, Shahriar
[PubMed]
[Google Scholar]
Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, Groningen - The Netherlands
- Blanquer, Sebastien
[PubMed]
[Google Scholar]
Department of Biomaterials Science and Technology, University of Twente, Enschede - The Netherlands
- Grijpma, Dirk W.
[PubMed]
[Google Scholar]
Department of Biomedical Engineering, University Medical Centre Groningen and University of Groningen, Groningen - The Netherlands and Department of Biomaterials Science and Technology, University of Twente, Enschede - The Netherlands
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