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< Vol. 12 Issue 3 | Sep-Dec 2014 | pp. 113 - 285

Release kinetics of anti-inflammatory drug, and characterization and bioactivity of SiO2+PCL hybrid material synthesized by 
sol-gel processing

Abstract

Background: Controlled and local drug delivery systems of anti-inflammatory agents are drawing increasing attention thanks to their possible pharmaceutical and biomedical applications. These systems have extended therapeutic effects and reduced side effects.
Methods: A single-step sol-gel process was used to prepare organic-inorganic hybrid materials based on silica (SiO2) 
and poly-ε-caprolactone, containing ketoprofen for controlled drug delivery applications. Fourier transform infrared spectroscopy analysis proved formation of H-bonds among the carbonyl groups of the polymer chains and Si-OH group of the inorganic matrix. X-ray diffraction analysis highlighted the amorphous nature of the synthesized materials. Scanning electron microscopy and atomic force microscope topography showed their homogeneous morphology and nanostructure nature.
Results: The bioactivity of the synthesized hybrid materials was shown by the formation of a layer of hydroxyapatite on the surface of samples soaked in a simulated body fluid (SBF).
Conclusion: Release kinetics in SBF were subsequently investigated by means of UV-VIS spectroscopy. A large amount of drug release occurred during the first few hours, then a slower drug release supplied a maintenance dose until the end of the experiment.

J Appl Biomater Funct Mater 2014; 12(3): 218 - 227

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.5000160

Authors

Michelina Catauro, Flavia Bollino

Article History

  • • Accepted on 12/03/2013
  • • Available online on 14/01/2014
  • • Published online on 30/12/2014

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Authors

  • Catauro, Michelina [PubMed] [Google Scholar]
    Department of Mechanical and Aerospace Engineering, Second University of Naples, Aversa, Caserta - Italy
  • Bollino, Flavia [PubMed] [Google Scholar]
    Department of Mechanical and Aerospace Engineering, Second University of Naples, Aversa, Caserta - Italy

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