Abstract
Aim: Until recently, only fibrin glue has been available for clinical usage to repair articular cartilage, although its adhesiveness is not strong enough for use with articular cartilage, and it is derived from human blood and thus carries the risk of contamination. Recently, LYDEX, a new biodegradable hydrogel glue, has come onto the market. The purpose of this study was to evaluate the adhesive strength and cytotoxicity of LYDEX when used on articular cartilage. Materials and Methods: The differing adhesive strengths of collagen membrane and articular cartilage with LYDEX versus with fibrin glue were measured using a tensile tester. In addition, the cytotoxity of LYDEX in vitro was evaluated. The cytotoxity of LYDEX for the articular cartilage of rats was evaluated histopathologically. Results: The adhesive strength of LYDEX was significantly stronger than that of fibrin glue, giving values about 3.8 times higher. LYDEX has no discernible effect on normal articular cartilage. Conclusions: Our study is the first to assess the usefulness and safety of LYDEX for use on articular cartilage.
J Appl Biomater Funct Mater 2013; 11(3): 180 - 186
Article Type: ORIGINAL RESEARCH ARTICLE
DOI:10.5301/JABFM.5000164
Authors
Hiromi Kazusa, Tomoyuki Nakasa, Hayatoshi Shibuya, Shingo Ohkawa, Goki Kamei, Nobuo Adachi, Masataka Deie, Naoki Nakajima, Suong-Hyu Hyon, Mitsuo Ochi
Article History
- • Accepted on 28/11/2012
- • Available online on 15/10/2013
- • Published online on 16/12/2013
This article is available as full text PDF.
Authors
- Kazusa, Hiromi
[PubMed]
[Google Scholar]
Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Nakasa, Tomoyuki
[PubMed]
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Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Shibuya, Hayatoshi
[PubMed]
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Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Ohkawa, Shingo
[PubMed]
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Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Kamei, Goki
[PubMed]
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Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Adachi, Nobuo
[PubMed]
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Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Deie, Masataka
[PubMed]
[Google Scholar]
Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
- Nakajima, Naoki
[PubMed]
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Institute for Frontier Medical Sciences, Kyoto University, Kyoto - Japan
- Hyon, Suong-Hyu
[PubMed]
[Google Scholar]
Institute for Frontier Medical Sciences, Kyoto University, Kyoto - Japan
- Ochi, Mitsuo
[PubMed]
[Google Scholar]
Department of Orthopedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima - Japan
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