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< Vol. 13 Issue 3 | Jul-Sep 2015 | pp. e195 - e299

Synthesis, characterization of dextran hydrogels and their in vitro release of gentamycin sulphate

Abstract

Purpose

This study reports on the synthesis and characterization of biodegradable dextran–allyl isocyanate–ethylamine (Dex-AE)/polyethylene glycol–diacrylate (PEGDA) hydrogels for the controlled release of gentamycin sulphate (GS) and in vitro inhibition of organisms.

 Methods

The Dex-AE precursor was prepared through a 2-step chemical modification and characterized by Fourier transform infrared spectroscopy (FTIR).

 Results

Scanning electron microscopy (SEM) results revealed that an increase in Dex-AE content led to an initial decrease in pore size of the Dex-AE/PEGDA hydrogels, but a further increase in Dex-AE content resulted in a slightly increase of pore size. The swelling data indicated that the swelling ratio depended on the precursor feed ratio. GS was incorporated into the hydrogels through 2 different methods, i.e., immersed and crosslinked. The crosslinked GS-Dex-AE/PEGDA hydorgels exhibited stronger antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Finally, the viscoelastic properties of crosslinked GS-Dex-AE/PEGDA hydorgels were investigated.

J Appl Biomater Funct Mater 2015; 13(3): e228 - e233

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/jabfm.5000233

Authors

Rui Guo, Peizhe Chen, Yunfei Mo, Yong Lan, Wei Xue, Yuanming Zhang

Article History

  • • Accepted on 25/02/2015
  • • Available online on 08/09/2015
  • • Published online on 16/10/2015

Disclosures

Financial support: This study was supported financially by the Natural Science Foundation of China (51303064), Natural Science Foundation of Guangdong (S2012040008003), the Key Project of DEGP (cxzd1109), the Ph.D. Programs Foundation of the Ministry of Education of China (20124401120015), and the Fundamental Research Funds of the Central Universities (21612327).
Conflict of interest: The authors declare that there is no conflict of interest.

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Authors

Affiliations

  • Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Jinan University, Guangzhou - China
  • Department of Biomedical Engineering, Jinan University, Guangzhou - China
  • Department of Chemistry, Jinan University, Guangzhou - China

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