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< Vol. 11 Issue 3 | Sep-Dec 2013 | pp. 129 - 196

The efficacy of bioceramics for the closure of burr-holes in craniotomy: Case studies on 14 patients

Abstract

Purpose: Bioceramics are currently in use to cover bone defects in orthopedics and craniofacial surgery. But their compatibility and efficacy in cranium were not investigated in detail. The aims of this study were to produce, characterize, and assess the biocompatibility and osteointegration of Si-HA, Si-Sr-HA, HA-Wollastonite, and HA-Wollastonite-Frit bioceramics. Methods: Bioceramics were implanted into the burr holes of 14 craniotomy patients who were followed up from three to 24 months. Radiologic and scintigraphic examinations were performed. Results: Osteoblastic activity quantified by scintigraphy increased from 6.865 to 22.991±1.682 from four to eight months in the HA-Woll group. Adding fritt into HA-Woll decreased osteoblastic activity at 10 months. Si-Sr-HA displayed significantly higher osteoblastic activity when compared to the craniotomy site at 12 months. The scintigraphic ratio of the bioceramic implanted regions to the craniotomy sites varied between 1.10 and 1.57. Osteoblast formation and establishment of the trabecular pattern of bone was observed in the surroundings of bioceramics in two patients. Conclusion: These bioceramics can be safely used to cover the burr holes of craniotomy patients, as well as to close the cranial bone defects.

J Appl Biomater Funct Mater 2013; 11(3): 187 - 196

Article Type: ORIGINAL RESEARCH ARTICLE

DOI:10.5301/JABFM.2012.9252

Authors

Yusuf Izci, Halil Ibrahim Seçer, Ahmet Turan Ilica, Ozgur Karaçalioglu, Onder Onguru, Muharrem Timuçin, Feza Korkusuz

Article History

  • • Accepted on 06/03/2012
  • • Available online on 22/06/2012
  • • Published online on 16/12/2013

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Authors

  • Izci, Yusuf [PubMed] [Google Scholar]
    Department of Neurosurgery, Gulhane Military Medical Academy, Ankara - Turkey
  • Seçer, Halil Ibrahim [PubMed] [Google Scholar]
    Department of Neurosurgery, Gulhane Military Medical Academy, Ankara - Turkey
  • Ilica, Ahmet Turan [PubMed] [Google Scholar]
    Department of Radiology, Gulhane Military Medical Academy, Ankara - Turkey
  • Karaçalioglu, Ozgur [PubMed] [Google Scholar]
    Department of Nuclear Medicine, Gulhane Military Medical Academy, Ankara - Turkey
  • Onguru, Onder [PubMed] [Google Scholar]
    Department of Pathology, Gulhane Military Medical Academy, Ankara - Turkey
  • Timuçin, Muharrem [PubMed] [Google Scholar]
    Department of Metallurgical and Materials Engineering, Faculty of Engineering, Middle East Technical University, Ankara -Turkey
  • Korkusuz, Feza [PubMed] [Google Scholar]
    Department of Physical Education and Sports, Faculty of Education, Middle East Technical University, Ankara, Turkey

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